Annotated protein:Neurexin-1-beta (Neurexin I-beta). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P0DI97
antibody wiki:
SynGO gene info:SynGO data @ NRXN1
Ontology domain:Cellular Component
SynGO term:integral component of presynaptic membrane (GO:0099056)
Synapse type(s):hippocampus
Annotated paper:Chamma I, et al. "Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy" Neurophotonics. 2016 Oct;3(4):041810 PMID:27872870
Figure(s):Figs. 1, 2, 3
Annotation description:The authors use super-resolved tracking of a tagged Neurexin-1beta in live cultured hippocampal neurons. The results show that Neurexin-1beta sorts to presynaptic sites (Fig. 1), where it forms 1 to 2 nanoclusters per terminal while a dispersed population is additionally present in terminals (Fig. 1, 2, 3).
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Super resolution
Annotator(s):Tony Cijsouw (ORCID:0000-0003-0912-1514)
Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
Additional literature:The authors performed super-resolved tracking of a Neurexin-1beta construct that was tagged differently than in the primary reference of this annotation. The results in Fig. 5 support that presynaptic sites contain Neurexin-1beta clusters in live cultured hippocampal neurons. @ PMID:26979420

Fig. 5 and Table 1 of this study support the localization of Neurexin-1beta to presynaptic membranes as determined by the biochemical sub-fractionation of synaptosomes and immunoblotting. @ PMID:17868325
SynGO annotation ID:900
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology