| Annotated protein: | Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]. Gene symbol: TENM2. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9NT68-2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TENM2 |
| Ontology domain: | Biological Process |
| SynGO term: | retrograde trans-synaptic signaling by trans-synaptic protein complex (GO:0098942) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Silva JP, et al. "Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities" Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12113-8 PMID:21724987 |
| Figure(s): | Fig. 6 |
| Annotation description: | Fig.6 shows that the stimulation of hippocampal neurons with the soluble ectodomain of the postsynaptically anchored protein Lasso results in an increase in presynaptic Ca2+ concentration. 1/11/2017 Pim - Although suggested by the authors the presynaptic effect of lasso exposure is not shown to be mediated by LPH1. I have refrained from suggesting the reciprocal annotation to this protein to the expert. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Optical physiology |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1017 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |