| Annotated protein: | Protein wntless (Evenness interrupted) (Sprinter). Gene symbol: WLS. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: Q95ST2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WLS |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Korkut C, et al. "Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless" Cell. 2009 Oct 16;139(2):393-404 PMID:19837038 |
| Figure(s): | Figure 5A-C |
| Annotation description: | The paper uses pre-embedding immunogold-Silver detection to study the subcellular localization of WLS in the fly neuromuscular junction. Wls is a multi-pass transmembrane glycoprotein essential for Wnt cell signaling. Figure 5F, 5J shows Wls/Evi at the presynaptic membrane (presynaptic compartment labelled in pink). Fig. 5G shows Wls/Evi at large presynaptic multi-membrane structures. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1029 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |