| Annotated protein: | LD33094p (Liprin-alpha, isoform A) (Liprin-alpha, isoform B). Gene symbol: LIPRIN-ALPHA. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: Q9VM93 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PPFIA1 SynGO data @ PPFIA2 SynGO data @ PPFIA3 SynGO data @ PPFIA4 |
| Ontology domain: | Biological Process |
| SynGO term: | presynapse assembly (GO:0099054) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Kaufmann N, et al. "Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis" Neuron. 2002 Mar 28;34(1):27-38 PMID:11931739 |
| Figure(s): | 4, 5, 8, 9 |
| Annotation description: | This publication demonstrates that in drosophila, liprin-a is involved in the assembly of presynaptic terminals at the NMJ. -dLiprin-a null have a reduced number of presynaptic terminals without affecting muscle innervation (figure 4, 5). The morphology of the remaining boutons is affected. Boutons are smaller (figure 5) and have larger active zones (figure 8). The latter is in line with findings in C. elegans (Zhen and Jin 1999). In line with a reduction in the number of boutons, mutants have reduced evoked EJP amplitude (Figure 9), demonstrating that the overal neurotransmitter release is reduced. In line with defects in presynaptic assembly, Miller et.al. (2005) shows that dLiprin-a null have defects in trafficking of presynaptic vesicles. dLiprin-a has 47% homology with human liprin-a, with up to 95% homology in its SAM domains. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Whole-cell patch clamp |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Miller et.al. demonstrates that dLiprin-alpha is required for trafficking of synaptic vesicles to the synapse. @ PMID:15823543 Zhen & Jin demonstrate that liprin null in C. elegans have enlarged active zones. @ PMID:10517634 |
| SynGO annotation ID: | 1037 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |