| Annotated protein: | Catenin delta-2. Gene symbol: CTNND2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35116 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CTNND2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | brain |
| Annotated paper: | Jones SB, et al. "Glutamate-induced delta-catenin redistribution and dissociation from postsynaptic receptor complexes" Neuroscience. 2002;115(4):1009-21 PMID:12453475 |
| Figure(s): | Figure 1b and 3 |
| Annotation description: | The paper demonstrates that an abundant signal for catenin delta can be detected in purified PSD fractions from rat brain using WB (Fig 1b). Figure 3 shows that delta-Catenin interacts with glutamate receptor complexes in brain. A WB signal for delta-Catenin can be found in IP fractions of PSD95, MgluR1alpha and NR2A (3A). The receptors can be detected in a delta-catenin IP sample (3B-D). 21/8/2017 Pim - Via PMID:9971746 the annotated gene was traced to rat CTNND2 (compared peptide sequences shown in Fig.1 PEPAPPPPPPP and KKKKKKK) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1038 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |