| Annotated protein: | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor). Gene symbol: ADRB2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P10608 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADRB2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hypothalamus, glutamatergic |
| Annotated paper: | Lee JG, et al. "beta(2)-Adrenoceptor-mediated facilitation of glutamatergic transmission in rat ventromedial hypothalamic neurons" Neuroscience. 2007 Feb 23;144(4):1255-65 PMID:17175110 |
| Figure(s): | Fig. 2, 3 |
| Annotation description: | Beta2 Adrenergic receptors (ARs) are G-Protein coupled receptors that facilitate synaptic transmission upon activation via a presynaptic mechanism involving adenylate cyclase activation and cAMP generation. Application of noradrenaline induces an increase in the mEPSC frequency in dissociated rat ventromedial hypothalamic neurons (Fig. 2A). This increase in mEPS frequency could not be blocked by the alpha1-AR antagonist prozocin or the beta1-AR antagonist atenol (Fig. 3B). However, it could be blocked by the application of the selective beta2-antagonist ICI-188551 and mimicked by application of the beta2-agonist formoterol (Fig. 3A, B, C). Inhibiting adenyl cyclase by the application of SQ22536, did not change the basal mEPSC frequency, but completely abolished NA-induced facilitation of the mEPSC frequency (Fig.4A, B). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| Additional literature: | Beta2 adrenergic receptors expressed in chinese hamster ovary cells bind adrenaline and noradrenaline (Table 2). @ PMID:1848818 |
| SynGO annotation ID: | 1098 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |