| Annotated protein: | RIMS-binding protein 2 (RIM-BP2). Gene symbol: RIMBP2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80U40 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RIMBP2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic active zone cytoplasmic component (GO:0098831) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Grauel MK, et al. "RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses" Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620 PMID:27671655 |
| Figure(s): | Figures 1A, S2G |
| Annotation description: | Using an specific antibody with knockout controls in STED microscopy, it is demonstrated that RIM-BP2 is localized in close proximity to Bassoon and Munc13-1. This shows that RIM-BP2 is localized to the active zone. This finding is in good agreement with STED microscopy performed in the fly NMJ (Liu et.al. 2011). 3/2/2017 Pim - Fig 3: STED - S2G: EM |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Super resolution |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | PMID:22174254 |
| SynGO annotation ID: | 111 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |