Annotated protein:Glutamate receptor ionotropic, kainate 4 (GluK4) (Excitatory amino acid receptor 1) (EAA1) (Glutamate receptor KA-1) (KA1). Gene symbol: GRIK4. Taxonomy: Homo sapiens (Human). Uniprot ID: Q16099
antibody wiki:
SynGO gene info:SynGO data @ GRIK4
Ontology domain:Biological Process
SynGO term:ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)
Annotated paper:Mott DD, et al. "Subunit-specific desensitization of heteromeric kainate receptors" J Physiol. 2010 Feb 15;588(Pt 4):683-700 PMID:20026616
Figure(s):fig.1B-D, fig.2
Annotation description:KA1 (kainate) receptor.

rule: NAS_MFCC-BP
rationale:
Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.
Pinf_CC:
[Q8BMF5] SyNGO ID 1120 (PMID:12954862, EM)
Evidence tracking, Biological System:Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Non-tracable Author Statement (NAS):This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):Niels Cornelisse (ORCID:0000-0001-9425-2935)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1129
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology