| Annotated protein: | Adenosine receptor A3 (TGPCR1). Gene symbol: ADORA3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P28647 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADORA3 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Dunwiddie TV, et al. "Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus" J Neurosci. 1997 Jan 15;17(2):607-14 PMID:8987783 |
| Figure(s): | Fig. 1-4 |
| Annotation description: | The adenosine A3 receptor is a G-protein coupled receptor involved in the modulation of synaptic transmission in concert with A1 receptors. Application of the selective A3R agonist Cl-IB-MECA to acute hippocampal slices has no effect on basal synaptic transmission or on LTP generation at Schaffer Collateral synapses (Fig. 1 and 2). Application of adenosine caused an inhibition of evoked inhibitory responses that is mediated by A1 receptors that could be blocked by co-application of the A3R agonist Cl-IB-MECA (Fig. 3c). This effect could be blocked by the A3 antagonist MRS 1191 (Fig. 4b). 17/8/2017 Pim - The effect on SV exocytosis may be indirect as stated in the discussion: "The present studies have demonstrated that selective activation or antagonism of adenosine A3 receptors alone has no direct effect on synaptic transmission or synaptic plasticity in the CA1 region of rat hippocampus. However, activation of these receptors reduces the sensitivity of presynaptic A1 receptors that inhibit glutamate release in this preparation, whereas responses to other presynaptic modulators at these synapses are unaffected. Based on these results, we hypothesize that an important role of A3receptors in brain may be to regulate the level of sensitivity of A1 receptors, which normally are tonically activated by low concentrations of endogenous adenosine." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1152 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |