| Annotated protein: | Syntaxin-1A (Neuron-specific antigen HPC-1) (Synaptotagmin-associated 35 kDa protein) (P35A). Gene symbol: STX1A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P32851 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX1A |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle exocytosis (GO:0016079) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Blasi J, et al. "Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin" EMBO J. 1993 Dec;12(12):4821-8 PMID:7901002 |
| Figure(s): | Fig. 1, Fig. 2 |
| Annotation description: | The authors show by combination of immunoblotting with functional assay (glutamate release assay) that Botulinum neurotoxin C1 is able to cleave specifically membrane-bound syntaxin-1 and this leads to inhibition of neurotransmitter release. 4/9/2017 Pim - Glutamate release from synaptosomal preparations measured with a photospectrometric assay. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Transmembrane transport assay |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| SynGO annotation ID: | 1160 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |