Annotated protein:Glutamate receptor ionotropic, kainate 5 (GluK5) (Glutamate receptor KA-2) (KA2). Gene symbol: GRIK5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63273
antibody wiki:
SynGO gene info:SynGO data @ GRIK5
Ontology domain:Cellular Component
SynGO term:integral component of presynaptic membrane (GO:0099056)
Synapse type(s):cerebral cortex
Annotated paper:Feligioni M, et al. "Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density" J Neurochem. 2006 Oct;99(2):549-60 PMID:16903873
Figure(s):Fig.5-6
Annotation description:Figure 5. KA2 (Kainate receptor subunit) measured with western blot in pre- and post-synaptic fractions (note that while detected presynaptically, it was enriched in postsynaptic fraction).

8/9/2017 Pim
- Experiments involve quantification of plasma membrane/surface levels of receptors via biotinylation assay.
- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Western blot
Biochemical fractionation (generic)
Annotator(s):Niels Cornelisse (ORCID:0000-0001-9425-2935)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1202
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology