Annotated protein:Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3). Gene symbol: GABRA3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P20236
antibody wiki:
SynGO gene info:SynGO data @ GABRA3
Ontology domain:Cellular Component
SynGO term:integral component of postsynaptic specialization membrane (GO:0099060)
Synapse type(s):hypothalamus, GABAergic
Annotated paper:Belenky MA, et al. "Presynaptic and postsynaptic GABAA receptors in rat suprachiasmatic nucleus" Neuroscience. 2003;118(4):909-23 PMID:12732237
Annotation description:Here we report on the subcellular localiza- tion of these receptors in the SCN, as revealed by an exten- sively characterized antibody to the

12/9/2017 Pim
- Literal: " Panel (e) shows presynaptic (arrow) and postsynaptic (arrowheads) location of immunogold particles, while a clear presynaptic expression (arrows) of GABAA receptor is in panel (f)"
- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Niels Cornelisse (ORCID:0000-0001-9425-2935)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1249
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology