| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3). Gene symbol: GABRA3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P20236 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | hypothalamus, GABAergic |
| Annotated paper: | Belenky MA, et al. "Presynaptic and postsynaptic GABAA receptors in rat suprachiasmatic nucleus" Neuroscience. 2003;118(4):909-23 PMID:12732237 |
| Figure(s): | Fig.8e |
| Annotation description: | Here we report on the subcellular localiza- tion of these receptors in the SCN, as revealed by an exten- sively characterized antibody to the 12/9/2017 Pim - Literal: " Panel (e) shows presynaptic (arrow) and postsynaptic (arrowheads) location of immunogold particles, while a clear presynaptic expression (arrows) of GABAA receptor is in panel (f)" - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1249 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |