Annotated protein:Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3). Gene symbol: GABRA3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P20236
antibody wiki:
SynGO gene info:SynGO data @ GABRA3
Ontology domain:Biological Process
SynGO term:ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)
Annotated paper:Eyre MD, et al. "Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor alpha subunit isoforms" J Neurosci. 2012 Apr 25;32(17):5853-67 PMID:22539847
Annotation description:Functional characterisation in HEK cells of overexpressed GABAAR alpha 1 and 3 subunints.

Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.
[P20236] SyNGO ID 1252 (PMID:12732237, EM)
Evidence tracking, Biological System:Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Non-tracable Author Statement (NAS):This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):Niels Cornelisse (ORCID:0000-0001-9425-2935)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1325
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology