| Annotated protein: | Cytoplasmic polyadenylation element binding protein 4. Gene symbol: CPEB4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZKL3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CPEB4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Huang YS, et al. "CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA" EMBO J. 2006 Oct 18;25(20):4865-76 PMID:17024188 |
| Figure(s): | fig 5b |
| Annotation description: | CPEB4 is detected in the PSD fraction from IP from hippocampal neurons 21 DIV. Adittionally, CPEB4 immunofluorescence seems to be enriched in areas juxtaposed to synaptophysin-positive pre-synapses (primary rat hippocampal neurons as decribed in Huang et al., 2002). 24/9/2017 Pim - Literal: "Finally, both CPEB3 and CPEB4, when fused to GFP, were detected in dendrites, often as puncta (Figure 5C)" - Literal: "Taken together, these data show that CPEB3 and CPEB4 are expressed in only partially overlapping regions of the brain; within hippocampal neurons, where both are expressed, they appear to be synaptic." - The mRNA translation data is too poorly shown in this paper lacking clear synaptic relevance although looking at AMPAR translation. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1345 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |