| Annotated protein: | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1). Gene symbol: GRIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35439 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN1 |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Bidoret C, et al. "Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule" Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31 PMID:19666514 |
| Figure(s): | Fig. 2, 3, 4 |
| Annotation description: | Fig.2: "NR2A- but not NR2B-containing NMDAR are required for LTD induction" (rat cerebellum, Zn antagonist) These NMDARs cano Fig.3: NR2A is exclusively located in the parallel fibers varicosities (presynapses) Fig.4: Electrophysiological characterisation of NR1 (+NR2A) overexposed in HEK cells using WC patch-clamp. 22/11/2017 Pim - NR1 is an obligatory subunit of NMDARs (see Fig.4) |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1353 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |