| Annotated protein: | IQ motif and SEC7 domain-containing protein 2. Gene symbol: IQSEC2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q5DU25 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IQSEC2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density membrane (GO:0098839) |
| Synapse type(s): | hippocampus cerebellum |
| Annotated paper: | Sakagami H, et al. "IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses" Neurosci Res. 2008 Feb;60(2):199-212 PMID:18164504 |
| Figure(s): | Fig. 6, 7, 9 |
| Annotation description: | Fig9 shows quantitative immuno-EM for BRAG1 in mouse hippocampus. The most gold particles are detected directly adjacent (within 30 nm, is about the size of the primary and secondary antibody combined) to the post-synaptic membrane with little particles detected at the presynaptic side. 25/10/2017 Pim - IQSEC2; BRAG1; IQ-ArfGEF binds PSD-95 a marker of the PSD. |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Western blot Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1361 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |