| Annotated protein: | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1). Gene symbol: CYFIP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TMB8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CYFIP1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of translation at postsynapse, modulating synaptic transmission (GO:0099578) |
| Synapse type(s): | neocortex |
| Annotated paper: | De Rubeis S, et al. "CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation" Neuron. 2013 Sep 18;79(6):1169-82 PMID:24050404 |
| Figure(s): | Fig. 1-3 |
| Annotation description: | 28/8/2017 Pim - CYFIP1 Is Part of Two Complexes, the WRC actin-regulatory complex and the FMRP-eIF4E translational complex (Fig.1) - BDNF-induced Rac1 activation inhibits CYFIP interaction with the FMRP-eIF4E translational complex (Fig.2) - Rac1 activation promotes CYFIP1 and FMRP-Dependent mRNA Translation of the synaptic target protein Arc (Fig.3). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Crystallography IP + WB/MSMS |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1371 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |