Annotated protein:Lethal giant larvae homologue 2 domain-containing protein (Tomosyn isoform A). Gene symbol: TOM-1. Taxonomy: Caenorhabditis elegans (Worm). Uniprot ID: Q49HI3
antibody wiki:
SynGO gene info:SynGO data @ STXBP5
Ontology domain:Biological Process
SynGO term:regulation of synaptic vesicle priming (GO:0010807)
Synapse type(s):Neuro-muscular junction
Annotated paper:Gracheva EO, et al. "Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans" PLoS Biol. 2006 Jul;4(8):e261 PMID:16895441
Figure(s):fig 2
Annotation description:tomosyn is a negative regulator of synaptic vesicle priming. in null worms the synaptic evoked response is increased and broader and compensates the reduced response of the known priming factor Munc13
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Annotator(s):Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1382
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology