Annotated protein:Lethal giant larvae homologue 2 domain-containing protein (Tomosyn isoform A). Gene symbol: TOM-1. Taxonomy: Caenorhabditis elegans (Worm). Uniprot ID: Q49HI3
antibody wiki:
SynGO gene info:SynGO data @ STXBP5
Ontology domain:Biological Process
SynGO term:regulation of synaptic vesicle priming (GO:0010807)
Synapse type(s):Neuro-muscular junction
Annotated paper:McEwen JM, et al. "Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13" Neuron. 2006 Aug 3;51(3):303-15 PMID:16880125
Figure(s):fig 1A-D, fig 4A-b
Annotation description:tomosyn is a negative regulator of synaptic vesicle priming. in null worms the synaptic response to hypertonic sucrose (which is a measure for the primed vesicle pool) is increased and broader and the reduced response of the known priming factor Munc13 is (partially) compensated
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Annotator(s):Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1384
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology