| Annotated protein: | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1). Gene symbol: GRIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35439 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Berg LK, et al. "Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses" Neuroscience. 2013 Jan 29;230:139-50 PMID:23159309 |
| Figure(s): | Fig.2A, Fig.4 |
| Annotation description: | Localisation of NMDR subunits with immunogold EM. 8/9/2017 Pim - Fig.4 show pre and postsynaptic localization in mossy fiber synapses. - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1385 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |