Annotated protein:Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1). Gene symbol: STXBP5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8K400
antibody wiki:
SynGO gene info:SynGO data @ STXBP5
Ontology domain:Biological Process
SynGO term:regulation of synaptic vesicle exocytosis (GO:2000300)
Synapse type(s):Mossy fiber synapse (DG->CA3)
Annotated paper:Sakisaka T, et al. "Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release" J Cell Biol. 2008 Oct 20;183(2):323-37 PMID:18936251
Figure(s):Fig 1 D-E
Annotation description:the evoked synaptic responses at hippocampal mossy fiber synapses in tomosyn-deficient mice is increased and the paired-pulse ratio decreased (indicative of reduced release probability)
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Annotator(s):Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1391
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology