| Annotated protein: | Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog). Gene symbol: KCNMA1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62976 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNMA1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hu H, et al. "Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release" J Neurosci. 2001 Dec 15;21(24):9585-97 PMID:11739569 |
| Figure(s): | fig. 1, 2 |
| Annotation description: | Immuno gold labeling of alpha subunit of BK channel 21/11/2017 Pim - Literal: "Taken together, these results indicate that BK channel α-subunits are targeted to the presynaptic active zone of hippocampal glutamatergic synapses." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chose. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1445 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |