| Annotated protein: | SH3 domain-containing protein. Gene symbol: ABI-1. Taxonomy: Caenorhabditis elegans (Worm). Uniprot ID: Q10929 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ABI1 SynGO data @ ABI2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic actin cytoskeleton organization (GO:0099140) |
| Synapse type(s): | brain |
| Annotated paper: | Stavoe AK, et al. "Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin" Genes Dev. 2012 Oct 1;26(19):2206-21 PMID:23028145 |
| Figure(s): | fig 6 |
| Annotation description: | Abl-interacting protein-1 (ABI-1)/Abi1, is a component of the WAVE complex, that organizes the actin cytoskeleton and promotes vesicle clustering at presynaptic sites. Using a mutant allele of abi-1 in C. elegans, the authors showed defective vesicle clustering at presynaptic sites. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 1454 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |