| Annotated protein: | Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein). Gene symbol: PPP1R1B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6J4I0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PPP1R1B |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | striatum, glutamatergic |
| Annotated paper: | Blom H, et al. "Spatial distribution of DARPP-32 in dendritic spines" PLoS One. 2013 Sep 10;8(9):e75155 PMID:24058659 |
| Figure(s): | Fig 1,2, and 4 |
| Annotation description: | Using immunocytochemistry and super-resolution STED microscopy, DARP-32 was found to be localized as clusters in dendritic spines of cultured striatal neurons. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 1455 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |