| Annotated protein: | Synapsin-1 (Synapsin I). Gene symbol: SYN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88935 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYN1 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle cycle (GO:0099504) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Rosahl TW, et al. "Short-term synaptic plasticity is altered in mice lacking synapsin I" Cell. 1993 Nov 19;75(4):661-70 PMID:7902212 |
| Figure(s): | Figs 5-6 |
| Annotation description: | Synapsin I KO mice are viable and show no effect on basal synaptic transmission. Mice lacking synapsin I exhibit a selective increase in paired pulse facilitation, with no major alterations in other synaptic parameters such as long-term potentiation. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Synapsin I KO mice show increased paired-pulse facilitation without effects on basal synaptic transmission or PTP or LTP. @ PMID:7777057 |
| SynGO annotation ID: | 1466 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |