| Annotated protein: | 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B). Gene symbol: HTR1B. Taxonomy: Mus musculus (Mouse). Uniprot ID: P28334 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR1B |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | hypothalamus, serotonergic |
| Annotated paper: | Pickard GE, et al. "5-HT1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus" J Neurosci. 1999 May 15;19(10):4034-45 PMID:10234032 |
| Figure(s): | Fig 2 and 3 |
| Annotation description: | Using electron microscopy of mouse suprachiasmatic nucleus (SCN) sections, the authors found that 5HT1b receptors were localized at the plasma membrane of axon terminals (presynaptic) of retinohypothalamic tract neurons that provide input to SCN. 21/11/2017 Pim - "Immunoreactivity was never seen within the region of synaptic specializations" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 1486 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |