| Annotated protein: | Metabotropic glutamate receptor 7 (mGluR7). Gene symbol: GRM7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35400 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRM7 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Bradley SR, et al. "Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies" J Neurosci. 1996 Mar 15;16(6):2044-56 PMID:8604049 |
| Figure(s): | Figure 10 |
| Annotation description: | A new antibody specific for the C-terminus of mGluR7 was raised and shown to react to mGluR7. EM of rat brain sections showed that mGluR7 was presynaptically localized to asymmetric synapses, though there were a few instances of postnsynaptic localization. 20/11/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 1581 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |