| Annotated protein: | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (Turned on after division 64 kDa protein) (TOAD-64). Gene symbol: DPYSL2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P47942 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DPYSL2 |
| Ontology domain: | Biological Process |
| SynGO term: | transport |
| Synapse type(s): | brain hippocampus spinal cord |
| Annotated paper: | Brittain JM, et al. "An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels" J Biol Chem. 2009 Nov 6;284(45):31375-90 PMID:19755421 |
| Figure(s): | Figs 2, 3, 4, 6 and 7 |
| Annotation description: | CRMP2 was shown to interact with CaV2.2. Overexpression of CRMP2 increases in surface levels of CaV2.2 and is associated with an increase in CaV2.2-mediated Ca2+ currents. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp IP + WB/MSMS Protein-protein interaction (generic) |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| Additional literature: | Over-expression of CRMP2 in DRG neurons increases cell surface CaV2.2 levels and CaV2.2-mediated Ca2+ currents in these cells without affecting activation or inactivation properties of the channel (Figs 3, 4, 5 and 9). @ PMID:19903690 |
| SynGO annotation ID: | 1628 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |