| Annotated protein: | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65). Gene symbol: APBB1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9QXJ1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ APBB1 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse organization (GO:0050808) |
| Synapse type(s): | hippocampus, glutamatergic Neuro-muscular junction Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Strecker P, et al. "FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation" Sci Rep. 2016 May 11;6:25652 PMID:27734846 |
| Figure(s): | Figs 3, 4, 5 |
| Annotation description: | Using fluorescence microscopy, APPBP1 KO mice were found to have a smaller density of spines in hippocampal CA1 neurons. The neurons exhibited reduced post-tetanic potentiation values and deficits in the maintenance of LTP. In addition, NMJ from APPBP1 KO mice show smaller pre- and postsynaptic areas and decreased aposition as compared to wild type controls. 10/102017 Pim - The authors mention that APBB1 is a scaffold protein and show effects on spine density after perturbation. LTP is affected. Moreover, the NJM structure is perturbed. Because of the known scaffolding function I agree with the expert that it is likely that organizing the synaptic structure is the prinicpal role of APBB1 and that effects on LTP are a consequence of this. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence Electrophysiology (generic) |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| SynGO annotation ID: | 1629 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |