| Annotated protein: | Pleckstrin homology domain containing, family A member 5. Gene symbol: PLEKHA5. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9Q6H8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PLEKHA5 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Pandya NJ, et al. "Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution" Sci Rep. 2017 Sep 21;7(1):12107 PMID:28935861 |
| Figure(s): | Figure 7, sTable 1 |
| Annotation description: | This protein shows biochemical enrichment in the PSD fraction of mouse hippocampus, cortex and cerebellum (sTable 1) and co-localizes with HOMER1 in 3D-SIM microscopy of mouse primary hippocampal neurons. 16/10/2017 Pim - Homer1 is used as a marker of the postsynapse. Antibodies used: anti-HOMER1 (1 in 1000, cat. no. 160 004, Synaptic systems) anti-PLEKHA5 (1 in 250, cat. no. sc-390311, Santa cruz) |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1665 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |