Annotated protein:Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1). Gene symbol: CADM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R5M8
antibody wiki:
SynGO gene info:SynGO data @ CADM1
Ontology domain:Biological Process
SynGO term:synapse assembly (GO:0007416)
Synapse type(s):hippocampus
Schaffer collateral synapse (CA3->CA1)
Annotated paper:Robbins EM, et al. "SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning" Neuron. 2010 Dec 9;68(5):894-906 PMID:21145003
Figure(s):Fig. 2
Annotation description:This study used a transgenic mouse model to test synaptic roles of SynCAM 1. Figs. 2A,B and 2F,G show that the overexpression of SynCAM 1 in excitatory neurons in vivo is sufficient to increase the number of excitatory synapses and of dendritic spines, a morphological correlate of excitatory synapses. The results in Fig. 5E demonstrate that this increase is lost when SynCAM 1 overexpression is turned off. These results support an instructive role of SynCAM 1 in the induction of excitatory synapses.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Electron Microscopy
Confocal
Electrophysiology (generic)
Annotator(s):Tony Cijsouw (ORCID:0000-0003-0912-1514)
Thomas Biederer (ORCID:0000-0002-3670-7863)
Lab:Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
SynGO annotation ID:1753
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology