| Annotated protein: | Neuron-specific calcium-binding protein hippocalcin (P23K). Gene symbol: HPCA. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P84076 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HPCA |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Dovgan AV, et al. "Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons" Eur J Neurosci. 2010 Aug;32(3):347-58 PMID:20704590 |
| Figure(s): | Fig.4, 5, 6 |
| Annotation description: | Fig.4: "Strong activation of synaptic NMDARs induced hippocalcin-YFP translocation to dendritic spines." Fig.5: "Activation of synaptic and total pools of NMDARs resulted in differential hippocalcin-YFP signalling in spines." Fig.6: "Intrinsic bursts of network activity induced hippocalcin-YFP translocation to dendritic spines" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1786 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |