| Annotated protein: | Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]. Gene symbol: GPC4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P51655 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPC4 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | brain |
| Annotated paper: | Trinidad JC, et al. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations" Mol Cell Proteomics. 2006 May;5(5):914-22 PMID:16452087 |
| Figure(s): | Suppl. Table S1 |
| Annotation description: | The supplemental table S1 contains 1264 proteins identified in the PSD preparation (Synaptic junctional protein preparation). The heparin sulfate proteoglycan, currently a potential association with synapses, is based on two proteomic studies. Synaptic glypican receptors are identified (see above). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This paper demonstrates that Glypican 4 that regulates release of neuronal Pentraxin 1 from axons to induce functional synapse formation. @ PMID:29024665 This paper discovers synaptic receptors for glypicans. @ PMID:23911103 |
| SynGO annotation ID: | 1897 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |