| Annotated protein: | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein). Gene symbol: EIF4E. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P63074 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EIF4E |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Tang SJ, et al. "A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus" Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72 PMID:11756682 |
| Figure(s): | fig 3 |
| Annotation description: | The figure shows the synaptic co-localization of eIF4E with synapse in hippocampal neurons (P2; 14 DIV), furthermore eIF4E colocalize with PSD-95, postsynaptic marker. 24/9/2017 Pim - Literal: "The mTOR-positive regions were observed in the dendritic shaft in a diffuse pattern that extended into synaptic regions (Fig. (Fig.33Al). Consistent with the notion of postsynaptic localization of these proteins, double labeling with PSD-95 showed the signals from eIF-4E, 4E-BP1, and mTOR at synaptic regions almost completely overlapped with PSD-95 signals." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1916 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |