| Annotated protein: | Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit). Gene symbol: GRID2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61625 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRID2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Matsuda K, et al. "Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer" Science. 2010 Apr 16;328(5976):363-8 PMID:20395510 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "Cbln1 directly promotes the clustering of GluD2 and other postsynaptic molecules" Cbln1 interacts with the postsynaptic protein GluD2. GluD2 clustered in Purkinje cells around beads coated with HA-Cbln1. With GluD2, shank-2, homer-3, and GluA2 clustered in Purkinje cells around the beads coated with HA-Cbln1. The clustering of PSD components is absent in neurons of GluD2 KO mice. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1932 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |