Annotated protein:Neurexin-1-beta (Neurexin I-beta). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P0DI97
antibody wiki:
SynGO gene info:SynGO data @ NRXN1
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic density assembly (GO:0099151)
Synapse type(s):cerebellum, glutamatergic
Annotated paper:Matsuda K, et al. "Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions" Eur J Neurosci. 2011 Apr;33(8):1447-61 PMID:21410790
Figure(s):Fig. 5
Annotation description:Fig.5: "NRX1β(S4+) functions as a postsynaptic organizer by forming a tripartite complex with Cbln1 and GluD2."
NRX1β(S4+)-conjugated beads induced clustering of endogenous GluD2 (green) and its associated postsynaptic protein shank2 (red) in cbln1-null Purkinje cells only in the presence of HA-Cbln1

20/11/2017 Pim
- The isoform of Nrx1beta was traced back to xxxx via PMID:16624946 using aa sequence 'GNND-NERLAIARQRIPYRLGRVVDEWLLDK' in blast search. This resulted 100% hits against reviewed Neurexin-1-beta sequences in rat (Q63373), mouse (P0DI97) and human (P58400).
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:1935
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology