Annotated protein:Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit). Gene symbol: GRID2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63226
antibody wiki:
SynGO gene info:SynGO data @ GRID2
Ontology domain:Biological Process
SynGO term:regulation of presynapse assembly (GO:1905606)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Matsuda K, et al. "Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions" Eur J Neurosci. 2011 Apr;33(8):1447-61 PMID:21410790
Figure(s):Fig. 7
Annotation description:Fig.7: "Cbln1 and Cbln2 serve as a presynaptic organizer in hippocampal neurons"
"Immunocytochemical analyses showed that HEK293 cells expressing GluD2 but not those expressing GluD2ΔNTD accumulated synaptophysin-positive presynaptic terminals of hippocampal neurons only when recombinant HA-Cbln1 protein was added to the culture medium (Fig. 7A)."
Evidence tracking, Biological System:Cultured neurons
Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:1938
Dataset release (version):20210225
View annotation as GO-CAM model:Gene Ontology