| Annotated protein: | 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B). Gene symbol: HTR1B. Taxonomy: Cricetulus griseus (Chinese hamster). Uniprot ID: P46636 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR1B |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hypothalamus, serotonergic |
| Annotated paper: | Pickard GE, et al. "5-HT1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus" J Neurosci. 1999 May 15;19(10):4034-45 PMID:10234032 |
| Figure(s): | Fig.4, 6, 8, 9 |
| Annotation description: | 21/11/2017 Pim In Fig.4+6+8+9 the authors show that: 1. Fig.4: TFMPP (5-HT1B receptor agonist), reduced in a dose-related manner the amplitude of glutamatergic EPSCs evoked by stimulating selectively the optic nerve (hamster SCN) 2. Fig.6: TFMPP had no effect on the amplitude of inward currents generated by local application of glutamate (hamster SCN) 3. Fig.8+9: Effect of TFMPP on circadian rhythm (mediated by SCN) is not observed in 5-HT1B receptor knock-out mice (mouse brain) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 1947 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |