| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-7. Gene symbol: CHRNA7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q05941 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA7 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Fabian-Fine R, et al. "Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus" J Neurosci. 2001 Oct 15;21(20):7993-8003 PMID:11588172 |
| Figure(s): | Fig. 4, 5, 8 |
| Annotation description: | presynaptic immuno gold labeling of nAChR alpha 7 in HC 21/11/2017 Pim - Literal: "The ultrastructural investigation of dentate gyrus and CA1 and CA3 regions revealed α7 nAChR-LIR at synaptic sites in all hippocampal areas (Fig. 5). Gold particles were located mainly (1) at the postsynaptic density, (2) within the synaptic cleft, (3) in the postsynaptic cytoplasm (Figs. 5-7), " |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1952 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |