| Annotated protein: | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) (mFmr1p). Gene symbol: FMR1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P35922 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FMR1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic cytosol (GO:0099523) |
| Synapse type(s): | hippocampus, glutamatergic olfactory bulb, glutamatergic Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Christie SB, et al. "The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits" J Neurosci. 2009 Feb 4;29(5):1514-24 PMID:19193898 |
| Figure(s): | Fig. 2g,h, Fig. 4c |
| Annotation description: | Immunogold electron microscopy showed that FMRP was localized in presynaptic specializations of olfactory glomeruli synapses (fig. 2g,h)and mossy fiber terminals (fig. 4c). 20/2/2017 Pim: -cytosol inferred from EM pictures and absence of membrane-localizing domains. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 198 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |