| Annotated protein: | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP). Gene symbol: FMR1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q80WE1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FMR1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of translation at presynapse, modulating synaptic transmission (GO:0099577) |
| Synapse type(s): | spinal cord, glutamatergic |
| Annotated paper: | Ferron L, et al. "Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density" Nat Commun. 2014 Apr 7;5:3628 PMID:24709664 |
| Figure(s): | Fig. 4, Fig. 8 |
| Annotation description: | FMRP knockdown enhances synaptic vesicle exocytosis in presynaptic terminals of DRG neurons via regulating the translation and the surface expression of CaV2.2 channels. 20/2/2017 Pim: -Fig.4: FRMP promotes proteasomal degradation of CaV2.2 channels -Fig.8: FMRP knockdown enhances synaptic vesicle exocytosis in presynaptic terminals of DRG neurons via CaV2.2 channels. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Optical physiology |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 199 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |