| Annotated protein: | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) (mFmr1p). Gene symbol: FMR1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P35922 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FMR1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of translation at postsynapse, modulating synaptic transmission (GO:0099578) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Huber KM, et al. "Altered synaptic plasticity in a mouse model of fragile X mental retardation" Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50 PMID:12032354 |
| Figure(s): | Fig. 2 |
| Annotation description: | Brief application of the mGluR agonist DHPG (5 min; 100M) induces greater LTD of synaptic responses in hippocampus of Fmr1-KO mice as compared with WT littermate controls. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Fig. 1 confirms the interaction of FMR1 with the translation initiation complex in the presence of CYFIP1. Fig. 6 demonstrate that this complex is actively regulated at synapses @ PMID:18805096 |
| SynGO annotation ID: | 200 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |