| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4). Gene symbol: GABRA4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P28471 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA4 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Liang J, et al. "Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors" J Neurosci. 2006 Feb 8;26(6):1749-58 PMID:16467523 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: "Postembedding immunogold labeling reveals a change in α4 but not in δ subunit location from perisynaptic to synaptic sites in the molecular layer of the dentate gyrus after CIE treatment." 6/12/2017 Pim - importatnt to note here is that small basic amounts of alpha4 are present in the postsynaptic specialization and that these levels are increased by EtOH exposure. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2085 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |