| Annotated protein: | Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin leucine rich transmembrane protein 3). Gene symbol: FLRT3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BGT1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FLRT3 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | O'Sullivan ML, et al. "FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development" Neuron. 2012 Mar 8;73(5):903-10 PMID:22405201 |
| Figure(s): | figure 2,3 |
| Annotation description: | Fig.2,3; The authors use both a dom neg FLRT3 protein and a shRNA knockdown and observe a reduction in the number of exc. synapses. The membrane adhesion part of FLRT3 with LPHN3 is shown directly by co-cultured LPHN3-GFP expressing neurons and FLRT3 expressing HEK cells that induces clustering of LPHN3. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2103 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |