Annotated protein:Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha). Gene symbol: DAGLA. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6WQJ1
antibody wiki:
SynGO gene info:SynGO data @ DAGLA
Ontology domain:Biological Process
SynGO term:retrograde trans-synaptic signaling by endocannabinoid (GO:0098921)
Synapse type(s):hippocampus
cerebellum
striatum
Annotated paper:Tanimura A, et al. "The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission" Neuron. 2010 Feb 11;65(3):320-7 PMID:20159446
Figure(s):Fig.2, 3
Annotation description:Fig.2: "Endocannabinoid-Mediated Retrograde Suppression Is Absent in the Cerebellum of α-KO Mice"

Fig.3: "Endocannabinoid-Mediated Retrograde Suppression Is Absent in the Hippocampus and Striatum of α-KO Mice"

Note1: the retrograde aspect of the effect is demonstrated by the effect of depolarization of the postsynaptic cell that has effects on the presynaptic release of neurotransmitter.
Note2: The effect is shown to be on GABAergic and Glutamatergic synaptic currents in the hippocampus and striatum. I did not have sufficient space in the menus to accomodate this combinatorial complexity.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2114
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology