| Annotated protein: | Myosin heavy chain 10. Gene symbol: MYH10. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: G3V9Y1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYH10 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of modification of postsynaptic actin cytoskeleton (GO:1905274) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Rex CS, et al. "Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation" Neuron. 2010 Aug 26;67(4):603-17 PMID:20797537 |
| Figure(s): | Fig.1 |
| Annotation description: | Background: Myosin IIb is a known actin based motor that consists of multiple subunits. The Myh10 gene encodes the heavy chain of this complex. Fig.1: "Myosin IIb is required for stable LTP and activity-related spine actin polymerization" KD of MYH10 in the hippocampus CA1 area does not affect basal neuronal communication but impairs stability of LTP induction. "Slices expressing MyH10-shRNAs demonstrated significantly depressed levels of activity-induced spine F-actin structures" The rest of the experiments detail this the role of Myosin IIb, but are not specific at the Myh10 gene level. Fig.3: NMDA receptor stimulation and LTP induction triggers one or more second messenger systems (tested with ROCK inhibition) that activate the myosin II motor. Together: "In vivo delivery of shRNAs that targeted MyH10, the heavy chain of Myosin IIb, prevented F-actin polymerization and stable LTP." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal Field recordings |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 2140 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |