| Annotated protein: | Importin subunit alpha. Gene symbol: KPNA2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6P6T9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KPNA2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse to nucleus signaling pathway (GO:0099527) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Dieterich DC, et al. "Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus" PLoS Biol. 2008 Feb;6(2):e34 PMID:18303947 |
| Figure(s): | Fig.7 |
| Annotation description: | Fig.7: Note: the authors show that activation (via disinhibition of afferent neurons using bicuculline) of synaptic NMDA receptors induce the translocation of jacob and importin-alpha1 to the nucleus. Caldendrin competes with importin-alpha1 at the synapse. Note: This paper mentions to study 'Importin-α1'. The antibody used is Purified Mouse Anti-Karyopherin α Clone 2/Karyopherin α of db biosciences directed against Human Rch-1 aa. 254-497. This paper therefore investigates KPNA2, Karyopherin subunit alpha-2, Importin subunit alpha-1, SRP1-alpha protein. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 2155 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |