| Annotated protein: | Homer protein homolog 1 (PSD-Zip45) (VASP/Ena-related gene up-regulated during seizure and LTP 1) (Vesl-1). Gene symbol: HOMER1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z214 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HOMER1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Tu JC, et al. "Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins" Neuron. 1999 Jul;23(3):583-92 PMID:10433269 |
| Figure(s): | Figure 6 |
| Annotation description: | This paper identifies Homer1b/c as a Shank-interacting protein and uses immuno-EM to demonstrate localization in the PSD. Note: HOMER1a does not have this CC (see SynGO ticket #239). 9/3/2017 Pim: -Homer1b/c isoforms are different from Homer1a. I have made this annotation against the general Homer1 protein accession since this describes the general idea on the homer gene localization. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 219 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |