| Annotated protein: | Glypican 4. Gene symbol: GPC4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q642B0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPC4 |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of presynaptic membrane (GO:0099026) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | de Wit J, et al. "Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development" Neuron. 2013 Aug 21;79(4):696-711 PMID:23911103 |
| Figure(s): | fig 3G, 4 |
| Annotation description: | GPC4/VGlut1-positive puncta were juxtaposed to PSD-95 puncta, suggesting that GPC4 also localizes to excitatory presynaptic terminals in vivo. GPC4 showed little colocalization with the pre- and postsynaptic inhibitory markers VGAT and gephyrin. 28/12/2017 Pim - Based on the lipid anchor of the protein, the "anchored component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2208 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |